反应详情

N-(3-trifluoromethyl-phenyl)-acetamide (2.8 g, 13.7 mmol) was added in small portions to the cold fuming nitric acid (10 mL) taken in a dry round bottom flask at −10° C. The reaction mixture was stirred for another 10 minutes at the same temperature then quenched with water (50 mL) and extracted with ethyl acetate. The combined organic layers were dried over sodium sulphate and concentrated to dryness. The obtained residue was purified by column chromatography using 20% ethylacetate in hexane to get the title compound as yellow solid (0.9 g, 27.74%).

1. customtaken in a dry round bottom flask at −10° C
2. customthen quenched with water (50 mL)
3. extractionextracted with ethyl acetate
4. dry with materialThe combined organic layers were dried over sodium sulphate
5. concentrationconcentrated to dryness
6. customThe obtained residue was purified by column chromatography