Acetyl chloride → N-(2-Acetylphenyl)acetamide

To an ice cold slurry of the 1-(2-amino-phenyl)-ethanone (2 g, 14.79 mmol) in dichloroethane (10 mL), acetyl chloride (1.22 g, 16.2 mmol) was added slowly. The reaction mixture was warmed to room temperature and stirred for 2 h. After completion of the reaction, the reaction mixture was quenched with water (10 mL) and extracted with dichloromethane (2×25 mL). The combined organic layers were washed with an aq. solution of 5% NaHCO3 followed by water and brine, then dried over anhydrous sodium sulphate and concentrated to dryness. The obtained residue was purified by column chromatography using 2% ethyl acetate in hexane to obtain the title compound as off-white solid which directly used for the next reaction.

1. customAfter completion of the reaction
2. customthe reaction mixture was quenched with water (10 mL)
3. extractionextracted with dichloromethane (2×25 mL)
4. washThe combined organic layers were washed with an aq. solution of 5% NaHCO3
5. dry with materialdried over anhydrous sodium sulphate
6. concentrationconcentrated to dryness
7. customThe obtained residue was purified by column chromatography

ORD record

ord-09431f2e228748049a20b97d96a03820

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09006454B2