1-(2-Amino-3-nitrophenyl)ethan-1-one → 1-(2,3-Diaminophenyl)ethanone

HRID 1470648Notes

Reaction equation

HRID 1470648 reaction equation
[NH2:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:11](=[O:13])[CH3:12].[H][H]>[Pd].CO>[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:11](=[O:13])[CH3:12]

Participants

5

Reactant 2

HCID 125003861-(2-Amino-3-nitrophenyl)ethan-1-oneHCID 178418361HCID 178418361, compound

Product 1

HCID 184138171-(2,3-Diaminophenyl)ethanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A slurry of 1-(2-amino-3-nitro-phenyl)-ethanone (0.2 g, 1.11 mmol) and 10% palladium on carbon (0.020 g) in methanol (10 mL) was hydrogenated with a hydrogen balloon for 2 h. After completion of the reaction, the reaction mixture was filtered and evaporated under vacuum to obtain the title compound as off white solid (0.120 g, 72.28%)

Workup

  1. customAfter completion of the reaction
  2. filtrationthe reaction mixture was filtered
  3. customevaporated under vacuum

Sources & evidence

ORD record
ord-d65251c837d045bbab1401e177f10f44
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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