Acetone → 4-(4-cyanophenoxy)benzoic acid

HRID 1470650노트

반응식

HRID 1470650 반응식
[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2].CC(C)=[O:20]>>[C:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]([OH:20])=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2]

참가 물질

3

반응물 2

HCID 180AcetoneHCID 6138064-(4-Formylphenoxy)benzonitrile

생성물 1

HCID 21798064-(4-cyanophenoxy)benzoic acid수율 70%

실험 절차

To an ice cold solution of 4-(4-cyano-phenoxy)-benzaldehyde (2.0 g, 8.9 mmol) in acetone (10 mL), the Jone's reagent (7 mL) was added slowly drop wise until reaction completes. Acetone was removed completely and diluted with water. The mixture was extracted with ethyl acetate. the combined organic layers were dried over anhydrous sodium sulphate and concentrated to get the title compound (1.5 g, 70%)

후처리

  1. customwise until reaction
  2. customAcetone was removed completely
  3. additiondiluted with water
  4. extractionThe mixture was extracted with ethyl acetate
  5. dry with materialthe combined organic layers were dried over anhydrous sodium sulphate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0591465904c14d5196c6ca15e0368da8
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006454B2

반응 노트

불러오는 중…