Diazomethane → Methyl 2-amino-3-nitrobenzoate

Participants

Reaction Steps

To a solution of 2-amino-3-nitro-benzoic acid (6 g, 33 mmol) in methanol (20 mL), an ethereal solution of diazomethane gas was added until the staring material is completely consumed. The reaction mixture was then evaporated under reduced pressure and the crude resulting solid was purified by flash column chromatography using 5% ethylacetate & hexane as an eluent, to obtain 2 g of the required product as a yellow coloured solid.

Provenance & Evidence