Methyl 2-amino-3-nitrobenzoate → 2,3-Diaminobenzoic acid methyl ester

Participants

Reaction Steps

To a solution of 2-amino-3-nitro-benzoic acid methyl ester (2 g, 10 mmol) in methanol, a suspension of 10% Pd/C (300 mg) in methanol 5 mL was added and hydrogenated with a hydrogen balloon over a period of 8 h. The reaction mass was filtered and the filtrate was concentrated under reduced pressure to obtain 1.5 g of the required compound as a brown coloured solid (88%).

Provenance & Evidence