Diisopropylethylamine → HCID 66706295, compound

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2,3-Diaminobenzoic acid methyl ester	HCID 571825	—
Reactant	Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)	HCID 9886157	—
Reactant	HCID 19933666	HCID 19933666	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 66706295	HCID 66706295	—

Reaction Steps

To a stirred solution of 2,3-diamino-benzoic acid methyl ester (200 mg, 1.2 mmol), biphenyl benzoic acid (238 mg, 1.2 mmol), HATU (1.14 g, 3 mmol) in dry DMF (5 mL) was added diisopropylethyl amine (0.6 mL, 3.6 mmol). The mixture was stirred at ambient temperature overnight then poured into water (50 mL). The precipitated solid was filtered and dried in a vacuum oven to afford the required compound, which was used directly for the next step without any purification (300 mg, 72%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09006454B2
Source dataset	uspto-grants-2015_04
ORD ID	ord-a2114f4a27dc484982a29bbd326d35fc
Source note	uspto-grants-2015_04