HCID 66706295, compound → HCID 21689703, compound

HRID 1470657Notes

Reaction equation

HRID 1470657 reaction equation
[CH3:1][O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH:10][C:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:15][CH:14]=2)=O)[C:5]=1[NH2:25]>C(O)(=O)C>[CH3:1][O:2][C:3]([C:4]1[C:5]2[N:25]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)=[CH:15][CH:14]=3)[NH:10][C:6]=2[CH:7]=[CH:8][CH:9]=1)=[O:26]

Participants

3

Reactant 1

HCID 66706295HCID 66706295, compound

Product 1

HCID 21689703HCID 21689703, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
130 °C

Procedure

2-Amino-3-[(biphenyl-4-carbonyl)-amino]-benzoic acid methyl ester (300 mg, 0.86 mmol) was dissolved in glacial acetic acid (20 mL) and heated to 130° C. until the reaction was completed which was monitored by TLC (2 to 3 h). After the reaction is completed the solvent was removed and solid residue was purified over silica gel using chloroform and methanol as an eluent to get the required example 79.

Workup

  1. customwas monitored by TLC (2 to 3 h)
  2. customwas removed
  3. customsolid residue was purified over silica gel
  4. customto get the required example 79

Sources & evidence

ORD record
ord-efe4f487c3a0475cbb3866db9263c722
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

Loading…