Sodium Hydroxide → HCID 131732727, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4′-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,5,6-tetrafluoro-biphenyl-4-carboxylic acid methyl ester (2.6 g, 6.0 mmol) in tetrahydrofuran (50 mL) was added an aq. solution of 5 N sodium hydroxide (20 mL). The reaction mixture was stirred and refluxed for 5 hours. The progress of the reaction was monitored by TLC. The reaction mixture was concentrated. The resulting residue was cooled to 10° C. and acidified with an aq. solution of 50% HCl. The formed precipitate was filtered, washed thoroughly with water and dried to get colorless solid (2.2 g, 88.0%).

Provenance & Evidence