Diisopropylethylamine → HCID 131732729, compound

Participants

Reaction Steps

To a solution of 4′-(tert-butyl-dimethyl-silanyloxymethyl)-2,3,5,6-tetrafluoro-biphenyl-4-carboxylic acid (2.2 g, 5.3 mmol) in dry DMF (50 mL) was added 2,3-diamino-5-methyl-benzoic acid methyl ester (0.95 g, 5.3 mmol) and HATU (3.03 g, 7.9 mmol) followed by N,N-diisopropylethylamine (1 mL). The reaction mixture was stirred for 14 h at room temperature under nitrogen atmosphere. TLC shows completion of the reaction. The reaction mixture was quenched to crushed ice and the precipitate was filtered, washed with water and dried to get an off white solid (2.4 g, 80.80%) which was directly taken to the next step.

Provenance & Evidence