Cornforth reagent → HCID 58073906, compound

Participants

Reaction Steps

To a solution of 6-methyl-2-(2,3,5,6-tetrafluoro-4′-hydroxymethyl-biphenyl-4-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester (0.55 g, 1.22 mmol) in dry tetrahydrofuran (50 mL) was added pyridinium dichromate (0.2 g) portion wise. The reaction mixture was stirred at room temperature in nitrogen atmosphere for 14 hours. TLC shows completion of the reaction. The reaction mixture was filtered over celite bed and the filtrate was concentrated to dryness. The resulting residue was purified by column chromatography using 20% ethyl acetate in hexane to get to get the title compound as colorless solid (0.4 g, 74.07%).

Provenance & Evidence