Sodium Hydroxide → HCID 46947571, compound

Participants

Reaction Conditions

Reaction Steps

To the solution of 6-methyl-2-(2,3,5,6-tetrafluoro-4′-piperidin-1-ylmethyl-biphenyl-4-yl)-1H-benzoimidazole-4-carboxylic acid methyl ester (0.145 g, 0.283 mmol) in tetrahydrofuran (50 mL) was added an aq. solution of 5 N sodium hydroxide (10 mL). The reaction mixture was stirred at 60° C. for 4 hours. TLC shows completion of the reaction. The reaction mixture was cooled to room temperature, then concentrated and the obtained residue was acidified with an aq. solution of 50% HCl. The resulting precipitate was filtered and purified by preparative HPLC.

Provenance & Evidence