Water → HCID 68931295, compound

Participants

Reaction Steps

A solution of LiAlH4 (1.5 mL, 1.5 mmol, 1 M/THF) was added to a 0° C. solution of 5-4 (453 mg, 1.34 mmol) in THF (5 mL). After 3 h, H2O (5 mL) was added dropwise followed by dichloromethane and 15% NaOH (10 mL). The reaction was allowed to warm to room temperature and was stirred further for 30 min. The resulting mixture was extracted with dichloromethane (3×) and the combined dichloromethane solution was dried (Na2SO4), filtered and evaporated. Purification of the residue by flash chromatography on silica gel (Isco Combiflash unit) gave the title compound (447 mg, 97%).

Provenance & Evidence