Hydrochloric Acid → Benzoic acid, 2-amino-3-chloro-, methyl ester

Participants

Reaction Conditions

Reaction Steps

5.13 g (0.03 mol) of 2-amino-3-chlorobenzoic acid and 24 ml (0.59 mol) of methanol were added to a 100 ml four-necked flask equipped with a stirrer, a reflux condenser, a thermometer, and a dropping funnel, and a hydrogen chloride gas was blown in with stirring at 65° C. After 10 hours, the reaction solution was analyzed by HPLC by the absolute calibration method, and as a result, the yield was 75%.

Provenance & Evidence