4-[4-(2-acetylaminopropyl)phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester → 4-[4-(2-Acetylaminopropyl)phenyl]piperidine-1-carboxylic acid tert-butyl ester

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Reaction Steps

2.20 g (6.14 mmol) 4-[4-(2-Acetylamino-propyl)-phenyl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (VI.1) in 100 mL methanol are hydrogenated (50 psi) for 7.0 h at rt using 250 mg palladium on charcoal(10%). After that time, the catalyst is filtered off and the solvent is evaporated to yield the desired product.

Provenance & Evidence