Sodium borohydride → HCID 67125438, compound

Participants

Reaction Steps

To 13.60 g (32.0 mmol) (S)-1-benzyl-4-[4-(1-propionylamino-ethyl)phenyl]-pyridinium bromide (XXI.1) in 270 mL ethanol are slowly added 2.42 g (64.1 mmol) sodium borohydride at 0° C. The mixture is stirred for 48 h at rt. After that time, the solvent is removed in vacuo and ethyl acetate is added. The mixture is extracted with 1N HCl. The aq. phase is neutralized with 4N NaOH, the precipitate is filtered off and dried at 45° C. to yield the desired product.

Provenance & Evidence