2-Chloronicotinonitrile → (S)-N-(1-{4-[1-(3-Cyanopyridin-2-yl)piperidin-4-yl]phenyl}ethyl)acetamide

Participants

Reaction Conditions

Reaction Steps

50 μL (0.29 mmol) DIPEA are added to a mixture of 14 mg (0.10 mmol) 2-chloronicotinnitrile and 29 mg (0.11 mmol) (S)-N-[1-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (V.1) in 1.45 mL NMP. The mixture is stirred at 130° C. overnight. Subsequently the solvent is removed in vacuo, the residue is taken up in DMF and the mixture is purified using reversed phase HPLC (water/MeOH, 0.1% TFA) to yield the desired product.

Provenance & Evidence