2-Bromo-5-ethoxypyridine → (S)-N-{1-[4-(5'-Ethoxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl)-phenyl]-ethyl}-acetamide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

250 mg (1.24 mmol) 2-Bromo-5-ethoxy-pyridine are added to 250 mg (1.02 mmol) (S)-N-[1-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (V.1). The mixture is heated at 180° C. for 1 h. Subsequently the residue is taken up in DMF/methanol and the mixture is purified using reversed phase HPLC (column: Waters XBridge 5 μM; eluent A: water+0.3% NH4OH, eluent B: MeOH+0.3% NH4OH) to yield the desired product.

Herkunft & Nachweise