Diisopropylethylamine → (S)-N-(1-{4-[1-(6-Chloro-2-pyrrolidin-1-yl-pyrimidin-4-yl)-piperidin-4-yl]-phenyl}-ethyl)acetamide

Participants

Reaction Steps

To 22 mg (0.1 mmol) 4,6-dichloro-2-pyrrolidin-1-yl-pyrimidine in 1 mL THF are added 17 μL (0.1 mol) DIPEA and 25 mg (0.1 mmol) (S)—N-[1-(4-piperidin-4-yl-phenyl)ethyl]-acetamide (V.1). The mixture is stirred at rt over night. The solvent is removed in vacuo and the residue is purified using reversed phase HPLC (eluent A: water+0.1% TFA, eluent B: MeOH) to yield the desired product.

Provenance & Evidence