N-methylcyclopentanamine → HCID 67970517, compound

HRID 1470754Notes

Reaction equation

[CH3:1][NH:2][CH:3]1[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl[C:9]1[N:14]=[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([NH:30][C:31](=[O:33])[CH3:32])[CH3:29])=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[CH:12]=[CH:11][N:10]=1>C(#N)C>[CH:3]1([N:2]([CH3:1])[C:9]2[N:14]=[C:13]([N:15]3[CH2:16][CH2:17][CH:18]([C:21]4[CH:26]=[CH:25][C:24]([CH2:27][CH:28]([NH:30][C:31](=[O:33])[CH3:32])[CH3:29])=[CH:23][CH:22]=4)[CH2:19][CH2:20]3)[CH:12]=[CH:11][N:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

Conditions

Temperature: 150 °C

Procedure

181 μL (1.61 mmol) N-Methyl-cyclopentylamine are added to 120 mg (0.32 mmol) N-(2-{4-[1-(2-chloro-pyrimidin-4-yl)-piperidin-4-yl]-phenyl}-1-methyl-ethyl)-acetamide (XIV.2) in 3 mL acetonitrile. The mixture is heated at 150° C. for 30 min under microwave irradiation. After that time, the solvent is evaporated and the residue is purified using reversed phase HPLC (eluent A: water+0.1% TFA, eluent B: acetonitrile+0.1% TFA) to yield the desired product.

Workup

customAfter that time, the solvent is evaporated
customthe residue is purified

Sources & evidence

ORD record: ord-6b989fc0c7b649be8a5dd452c163baa5
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006450B2

Reaction notes

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