Benzoyl chloride → (S)-N-(1-{4-[1-(5-Phenyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-yl]-phenyl}-ethyl)acetamide

Participants

Reaction Conditions

Reaction Steps

0.019 mL (0.16 mmol) Benzoyl chloride are added to a mixture of 45.7 mg (0.15 mmol) (S)—N-(1-{4-[1-(N-hydroxycarbamimidoyl)-piperidin-4-yl]-phenyl}-ethyl)-acetamide (XXVII.2) and 0.063 mL (0.45 mmol) triethylamine in 4 mL THF. The mixture is stirred for 12 h at 80° C. and is subsequently purified by HPLC (RP C18 Sunfire; water (+0.1% TFA)/MeOH) to yield the desired product.

Provenance & Evidence