Potassium Carbonate → HCID 11149373, compound

Participants

Reaction Steps

This reaction is carried out in the same manner as the reaction in example 5. The difference is that, the reactans are (S)-3-methyl-4-chloride-5-phenyl-2(5H)— furanone (20.2 mg, 0.097 mmol), phenylboronic acid (19.0 mg, 98%, 0.15 mmol), palladium acetate (1.1 mg, 0.01 mmol), dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine tetrafluoroborate (2.5 mg, 0.0055 mmol), potassium carbonate (62.3 mg, 0.45 mmol) are reacted in 2 mL of anhydrous toluene at 110° C. for 6 minutes and 20.1 mg (S)-3-methyl-4,5-diphenyl-2(5H)-furanone is obtained. The yield is 83%, 99% ee.

Provenance & Evidence