HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 21940731, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-Chloro-3,5-dimethoxybenzene | HCID 81502 | — |
| Reactant | HCID 53354804 | HCID 53354804 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | HCID 21940731 | HCID 21940731 | 93% |
Reaction Steps
Under the protection of nitrogen, 0.05 equivalent of palladium acetate, 0.075 equivalent of dicyclohexyl(2,6-diisopropoxyphenyl)phosphine tetrafluoborate, 2.0 equivalent of potassium hydroxide, 1.0 equivalent of 3,5-dimethoxychlorobenzene and 1.2 equivalent of phenylamine were reacted in toluene at 110° C. for 3 hours. N-phenyl-N-methyl-3,5-dimethylphenylamine was obtained with a yield of 93%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006491B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-6acd0601f1a248399b9671434e77c5e0 |
| Source note | uspto-grants-2015_04 |