HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Hydroxyquinoline → HCID 19370029, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Hydroxyquinoline | HCID 1923 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1-Iodo-4-(trifluoromethoxy)benzene | HCID 2777294 | — |
| Reactant | 4-[1-(4-Trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile | HCID 66957107 | — |
| Reactant | HCID 178418936 | HCID 178418936 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| Product | HCID 19370029 | HCID 19370029 | 13% |
Reaction Steps
4-[1-(4-Trifluoromethoxyphenyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile. The triazole (70 mg, 0.41 mmol), 1-iodo-4-trifluoromethoxybenzene (142 mg, 0.493 mmol), Cs2CO3 (535 mg, 1.644 mmol), CuI (3 mg, 0.012 mmol), 8-hydroxyquinoline (2 mg, 0.012 mmol), and DMF/H2O (2 mL 10:1 solution) were combined in a 10 mL CEM Microwave reaction vessel fitted with magnetic stir bar and subjected to microwave irradiation at 150° C. for 30 min. The contents were then filtered and concentrated to dryness affording the 1,3-diphenyl triazole intermediate (18 mg, 13%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006468B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-63b60f1f39f14771a46230ccc037c66d |
| Source note | uspto-grants-2015_04 |