HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 3-bromothiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Bromothiophene-2-carboxylic acid | HCID 2739688 | — |
| Product | Methyl 3-bromothiophene-2-carboxylate | HCID 2740074 | — |
Reaction Steps
The 3-bromothiophene-2-carboxylic acid was first protected at the carboxylic group. 3-bromothiophene-2-carboxylic acid was dissolved in methanol containing catalytic DCC. Mixture was reacted by refluxing overnight. After solvent was evaporated, the residues were applied on silica gel. Methyl 3-bromothiophene-2-carboxylate was obtained as a colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006568B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-c4438f6b51134748bcb0f9b1a9d09385 |
| Source note | uspto-grants-2015_04 |