Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-Tert-Butylaniline | HCID 69861 | — |
| Reactant | 1,4-Bis(4-bromophenyl)-1,4-butanedione | HCID 219217 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 58226704 | HCID 58226704 | 90% |
Reaction Steps
To a solution of the product from Example 26E (4.00 g, 10.10 mmol) in toluene (40 mL) was added 4-tert-butylaniline (1.81 g, 12.12 mmol) followed by TFA (2.30 g, 20.20 mmol). Mixture heated to 110° C. for 2 h. Mixture cooled to room temperature and water and diethyl ether were added. Stirred for 15 min, filtered, washed with water and diethyl ether and dried to provide the title compound as a white solid (4.61 g; 90% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09006387B2 |
|---|
| Source dataset | uspto-grants-2015_04 |
|---|
| ORD ID | ord-0f6639ac455b47a69db6b8430acbcff2 |
|---|
| Source note | uspto-grants-2015_04 |
|---|
