反应详情

温度

45 °C

The product from Example 28C (2.9 g, 5.2 mmol) and 4-fluoroaniline (5.0 mL, 52.0 mmol) were combined, neat, and heated at 45° C. for 20 h then cooled and poured into water and extracted into dichloromethane. The organics were concentrated the residue was purified by chromatography on silica gel with a 120 g column, eluting with 0-5% ethyl acetate/hexanes to give 0.59 g (24%) of a thick oil.

1. temperaturethen cooled
2. extractionextracted into dichloromethane
3. concentrationThe organics were concentrated the residue
4. customwas purified by chromatography on silica gel with a 120 g column
5. washeluting with 0-5% ethyl acetate/hexanes