HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → 2,5-Bis(4-bromophenyl)-1-(4-tert-butylphenyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 1,4-Bis(4-bromophenyl)butane-1,4-diyl dimethanesulfonate | HCID 58226531 | — |
| Product | 2,5-Bis(4-bromophenyl)-1-(4-tert-butylphenyl)pyrrolidine | HCID 58226837 | 81% |
Reaction Steps
The product from Example 42B (5.2 g, 9.35 mmol) was subjected to the conditions described in Example 39D, substituting 4-tert-butylaniline (11.91 mL, 74.8 mmol) for 4-fluoroaniline to provide the title product (3.89 g, 81%) as a mixture of isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09006387B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-36184d768c404fdc8e81c65f7f336084 |
| Source note | uspto-grants-2015_04 |