Trifluoroacetic acid → HCID 67237682, compound

Participants

Reaction Conditions

Reaction Steps

TFA (0.6 mL, 7.79 mmol) was added to a mixture of the product from Example 39A (1.2335 g, 3.41 mmol) and 4-tert-butylaniline (0.8 mL, 5.07 mmol) in toluene (30 mL) and heated at 110° C. for 17 hours. The cooled reaction mixture was poured into ether/water and stirred until nice solid formed. The mixture was filtered to afford the title compound. 1H NMR (400 MHz, BENZENE-D6) δ 1.02 (s, 9H), 6.48 (d, J=3.8, 1H), 6.52 (d, J=3.8, 1H), 6.63 (d, J=8.5, 2H), 6.80 (d, J=8.5, 2H), 6.84 (d, J=8.9, 2H), 6.89 (d, J=8.5, 2H), 7.10 (d, J=8.5, 2H), 7.70 (d, J=8.9, 2H).

Provenance & Evidence