Ethanol → HCID 67381738, compound

Participants

Reaction Steps

The product from example 191E (1.18 g, 1.831 mmole) was dissolved in a mixture of THF (10 mL):EtOH (10 mL):EtOAc (10 mL), treated with PtO2 (42 mg) and evacuated 10 minutes, followed by introduction of H2 (g) via balloon. The reaction mixture was stirred overnight at room temperature. The next day, the reaction mixture was filtered and the solvent removed in vacuo leaving a dark green foamy solid. The solid was dissolved in 10 mL CH2Cl2 applied to a 40 g silica gel column and eluted with a gradient of hexane/EtOAc; 90/10 to 30/70 over 20 minutes. The title compound was isolated as a white foamy solid as a mixture of isomers 0.54 g, 48%.

Provenance & Evidence