4-(Trifluoromethyl)aniline → HCID 86649129, compound

HRID 1471054Notes

Reaction equation

HRID 1471054 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C@@H:10](O)[CH2:11][CH2:12][C@@H:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=2)O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=1>>[N+:1]([C:4]1[CH:5]=[C:6]([C@H:10]2[CH2:11][CH2:12][C@H:13]([C:15]3[CH:20]=[CH:19][CH:18]=[C:17]([N+:21]([O-:23])=[O:22])[CH:16]=3)[N:25]2[C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:28][CH:27]=2)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 99644-(Trifluoromethyl)anilineHCID 87378861HCID 87378861, compound

Product 1

HCID 86649129HCID 86649129, compoundYield 19%

Procedure

The product from Example 205A and 4-aminobenzotrifluoride were processed using the method described in Examples 55C and 55D to afford the title compound (0.27 g, 19%). MS (ESI) m/z 858 (M+H)+.

Sources & evidence

ORD record
ord-79d23ead148b48e9b1c23dcb6503b5f7
Source dataset
uspto-grants-2015_04
Patent number
US09006387B2

Reaction notes

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