反应详情

To a flask were added crude N-phenylbenzene-1,2-diamine, 9.7 g formamidine acetate and 175 ml 2-methoxyethanol and the mixture was heated to reflux under nitrogen for 30 minutes. After cooling to 22 C, the solvent was removed and the mixture was dissolved in ethyl acetate and washed with water. Following removal of the solvent, the product was purified by silica gel chromatography using 50% ethyl acetate in hexane giving a tan oil.

1. temperaturethe mixture was heated
2. temperatureto reflux under nitrogen for 30 minutes
3. temperatureAfter cooling to 22 C
4. customthe solvent was removed
5. dissolutionthe mixture was dissolved in ethyl acetate
6. washwashed with water
7. customremoval of the solvent
8. customthe product was purified by silica gel chromatography