Methanol → HCID 178446054, compound

HRID 1471299Notes

Reaction equation

HRID 1471299 reaction equation
[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[CH2:29]([OH:51])[C@H:30]1[O:35][C@H:34]([O:36][C@H:37]2[O:42][C@H:41]([CH2:43][OH:44])[C@@H:40]([OH:45])[C@H:39]([OH:46])[C@H:38]2[OH:47])[C@H:33]([OH:48])[C@@H:32]([OH:49])[C@@H:31]1[OH:50].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:35].[Br-:28].[CH2:43]([OH:44])[C@H:41]1[O:42][C@H:37]([O:36][C@H:34]2[O:35][C@H:30]([CH2:29][OH:51])[C@@H:31]([OH:50])[C@H:32]([OH:49])[C@H:33]2[OH:48])[C@H:38]([OH:47])[C@@H:39]([OH:46])[C@@H:40]1[OH:45].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56]

Participants

6

Reactant 4

HCID 887MethanolHCID 6106L-LeucineHCID 7427TrehaloseHCID 178480554HCID 178480554, compound

Product 1

HCID 178446054HCID 178446054, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Tiotropium bromide (1.2 g), trehalose dehydrate (0.6 g), and L-leucine (0.6 g) were dissolved into methanol (60 ml). The solutions were combined by shaking. Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined above.

Workup

  1. stirringshaken until dissolution
  2. customdried

Sources & evidence

ORD record
ord-a758c4c4395547e8bdf40db5d7464536
Source dataset
uspto-grants-2015_04
Patent number
US09011923B2

Reaction notes

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