Methanol → HCID 178446053, compound

HRID 1471301Notes

Reaction equation

HRID 1471301 reaction equation
[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:36].[Br-:28].[NH2:29][C@H:30]([C:35]([OH:37])=[O:36])[CH2:31][CH:32]([CH3:34])[CH3:33]

Participants

5

Reactant 3

HCID 887MethanolHCID 6106L-LeucineHCID 178480554HCID 178480554, compound

Product 1

HCID 178446053HCID 178446053, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Tiotropium bromide (1.4 g) and L-leucine (0.5 g) were dissolved into methanol (60 ml). Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined above.

Workup

  1. customdried

Sources & evidence

ORD record
ord-5888d6c0a9a142839b23b3e59bd924e5
Source dataset
uspto-grants-2015_04
Patent number
US09011923B2

Reaction notes

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