m-Chloroperbenzoic acid → HCID 86647585, compound

Participants

Reaction Conditions

Reaction Steps

At 5° C., a solution of methyl 7-methylspiro[4.5]dec-7-ene-6-carboxylate (13.5 g, 60 mmol, prepared as described in Example 25) in dichloromethane (150 ml) was treated with MCPBA (17.8 g, 72 mmol). The resulting mixture was stirred for 4 h at 20° C., filtered, and the organic phase was washed with water (100 ml), dried (MgSO4), concentrated, and gave crude methyl 1-methyl-7-oxaspiro[bicyclo[4.1.0]heptane-3,1′-cyclopentane]-2-carboxylate (13 g). Boiling point: 130° C. (0.08 mbar).

Provenance & Evidence