Hydrochloric Acid → HCID 68724101, compound

Participants

Reaction Steps

A solution of 8:92 cis/trans-10-acetyl-9-methylspiro[4.5]dec-8-en-7-yl acetate (4.1 g, 16.4 mmol) in DBU (30 ml) was stirred for 19 h at 40° C. The reaction mixture was poured into cold 2N aqueous HCl (100 ml), and extracted twice with cyclohexane (50 ml). The combined organic phases were washed with water (50 ml), with a saturated aqueous solution of NaCl (40 ml), dried (MgSO4), concentrated. FC (500 g SiO2, hexane/MTBE 50:1) of the crude product (2.92 g) gave methyl 1-(7-methylspiro[4.5]deca-6,8-dien-6-yl)ethanone (2.25 g, 72%).

Provenance & Evidence