HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 2,6-dichloronicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2,6-Dichloronicotinic acid | HCID 854047 | — |
| Product | Ethyl 2,6-dichloronicotinate | HCID 12263987 | 85.2% |
Reaction Steps
Esterification of 2,6-dichloronicotinic acid (25.5 g, 0.1328 mmol) in EtOH (200 proof, 200 mL) catalyzed with 96% H2SO4 (1.7 g) at refluxing temperature for 40 h under N2 gave the desired ethyl 2,6-dichloronicotinate as grey solid (24.89 g, 0.1131 mmol, yield 85.2%) after a normal work-up.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012431B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-fc5dab1233d34fb3a51592df74b286d6 |
| Source note | uspto-grants-2015_04 |