HRID1471755

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9321

Hydrazine

H4N2

结构：CN(C)/C=C/C(=O)c1ncccc1CO[Si](C)(C)C(C)(C)C

HCID86690729

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCc1cccnc1-c1ccn[nH]1

HCID86690793

未命名化合物

收率 90%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

To (E)-1-(3-((tert-butyldimethylsilyloxy)methyl)pyridin-2-yl)-3-(dimethylamino)prop-2-en-1-one (crude, 350 mg, 1.09 mmol, 1 eq.) in EtOH (5 mL) was added hydrazine (140 mg, 4.36 mmol, 4 eq.). The mixture was heated at 80° C. for 2 h, cooled, concentrated, and purified on silica gel using EtOAc as eluent to give 3-((tert-butyldimethylsilyloxy)methyl)-2-(1H-pyrazol-5-yl)pyridine (282 mg, 90%) as a white solid. LRMS (M+H+) m/z 290.1

WORKUP

后处理

temperaturecooled
concentrationconcentrated
custompurified on silica gel