Isobutylene oxide → 5-(2-Fluoro-4-methanesulfonyl-phenyl)-2-[1-(2-hydroxy-2-methyl-propyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethyloxirane (55 μL) is added to a solution of 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-piperidin-4-yl-furo[2,3-c]pyridine (0.15 g) in methanol (2 mL) and dichloromethane (3 mL) at room temperature. The solution is stirred at 50° C. overnight. The solution is concentrated to give the crude title compound that is used without further purification. LC (method 4): tR=0.98 min; Mass spectrum (ESI+): m/z=447 [M+H]+.

Provenance & Evidence