反应详情

Potassium tert-butoxide (2.80 g) and methyl iodide (3.60 mL) are added to an ice cold solution of 4-formyl-piperidine-1-carboxylic acid tert-butyl ester (4.00 g) in dichloromethane (24 mL). The mixture is stirred in the cooling bath for 30 min and then at room temperature overnight. Brine is added and the resulting mixture is extracted with dichloromethane. The combined extracts are dried (MgSO4) and concentrated to give the crude title compound that is used without further purification.

1. customat room temperature
2. customovernight
3. extractionthe resulting mixture is extracted with dichloromethane
4. dry with materialThe combined extracts are dried (MgSO4)
5. concentrationconcentrated