HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(methylsulphonyl)benzeneboronic acid → 4-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(methylsulphonyl)benzeneboronic acid | HCID 45933628 | — |
| Reactant | 4-(5-Chlorofuro[2,3-c]pyridin-2-yl)piperidine-1-carboxylic acid tert-butyl ester | HCID 86674889 | — |
| Product | 4-[5-(3-Fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 71736412 | — |
Reaction Steps
The title compound is prepared from 4-(5-chloro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester and 3-fluoro-4-methylsulfonyl-phenylboronic acid following a procedure analogous to that described for Example 1. LC (method 4): tR=1.71 min; Mass spectrum (ESI+): m/z=475 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012456B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-2f3f2234eba54102847af007a150eabd |
| Source note | uspto-grants-2015_04 |