HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate → 5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-(Trifluoromethyl)cyclopropyl)methyl methanesulfonate | HCID 86649942 | — |
| Reactant | 5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-furo[2,3-c]pyridine | HCID 86694580 | — |
| Product | 5-(1-Methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine | HCID 86694583 | — |
Reaction Steps
The title compound is prepared from 5-(1-methanesulfonyl-1,2,3,6-tetrahydro-pyridin-4-yl)-2-piperidin-4-yl-furo[2,3-c]pyridine and methanesulfonic acid 1-trifluoromethyl-cyclopropylmethyl ester following a procedure analogous to that described for Example 17. LC (method 1): tR=0.65 min; Mass spectrum (ESI+): m/z=484 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012456B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-a35107880c61481cbb536ddfa9543823 |
| Source note | uspto-grants-2015_04 |