Trifluoroacetic acid → HCID 57732997, compound

Participants

Reaction Steps

TFA (500 μL) was added to a solution of tert-butyl 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzylcarbamate (115 mg, 0.200 mmol) in CH2Cl2 (1.5 mL). The reaction was stirred at room temperature for 1 hour. The reaction was diluted with CH2Cl2 and 1N NaOH was added until the mixture become basic. The organic layer was dried over MgSO4, filtered and concentrated to yield N-(1-(3-(Aminomethyl)phenyl)isoquinolin-3-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide as a white solid (95 mg, 99%). ESI-MS m/z calc. 473.2. found 474.2 (M+1)+. Retention time 1.62 minutes.

Provenance & Evidence