反应详情

温度

50 °C

Phenyl(3-phenyloxiran-2-yl)methanone (5.0 g, 22.3 mmol) was suspended in dry Et2O (40 mL) under an argon balloon. Boron trifluoride diethyl etherate (3.00 mL, 23.7 mmol) was added slowly via syringe. The reaction was refluxed at 50° C. for an hour, then cooled and extracted with 60 mL each of H2O and Et2O/EtOAc. The aqueous layer was extracted again with EtOAc (60 mL). The combined organic layer was dried and concentrated to give 3-oxo-2,3-diphenylpropanal.

1. temperaturecooled
2. extractionextracted with 60 mL each of H2O and Et2O/EtOAc
3. extractionThe aqueous layer was extracted again with EtOAc (60 mL)
4. customThe combined organic layer was dried
5. concentrationconcentrated