Hydrazine hydrate (1:1) → HCID 67384919, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1-(dimethylamino)-2-phenylhex-1-en-3-one (3.51 g, 16.2 mmol) in ethanol (80.0 mL), was added hydrazine hydrate (1.57 mL, 32.4 mmol). The reaction mixture was stirred at 80° C. After 3 h, the reaction mixture was cooled to room temperature, concentrated under reduced pressure and crystallized in 20% ethanol/H2O to give the title compound as a white solid (3.01 g). LCMS m/z=187.1 [M+H]+; 1H NMR (400 MHz, CDCl3) δ ppm 0.92-1.00 (m, 3H), 1.64-1.76 (m, 2H), 2.75-2.84 (m, 2H), 7.36-7.41 (m, 5H), 7.65 (s, 1H).

Provenance & Evidence