HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 67384826, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | HCID 11615362 | HCID 11615362 | — |
| Reactant | 1-((1R)-((2R,4R,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)-4-((1R)-((2R,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methoxy)phthalazine | HCID 51003674 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 67384826 | HCID 67384826 | — |
Reaction Steps
To a solution of 5-(but-3-enyl)-3-phenyl-1H-pyrazole (3.0 g, 15.13 mmol) in iso-propanol (20 mL) and H2O (20 mL), was added AD-mix-α (20.0 g) at room temperature. The reaction was stirred for 48 h at room temperature. The reaction was poured into saturated Na2SO3 (20 mL) and extracted with ethyl acetate. The extract was dried over MgSO4 and concentrated under reduced pressure to give the title compound (2.45 g) as an oil, which was used without further purification. LCMS m/z=232.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012478B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-92c87af7f9ae40719f46345842a91a3a |
| Source note | uspto-grants-2015_04 |