p-Toluenesulfonic acid → HCID 67385068, compound

Participants

Reaction Steps

To a solution of (R)-4-(3-phenyl-1H-pyrazol-5-yl)butane-1,2-diol (2.5 g, 10.76 mmol) in acetone (50 mL), were added 2,2-dimethoxypropane (11.21 g, 108 mmol) and PTSA (0.185 g, 1.076 mmol) at room temperature. After stirring for 3 h, the reaction was concentrated under reduced pressure. The resulting residue was poured into water and extracted with ethyl acetate. The extract was dried over MgSO4 and concentrated under reduced pressure to give the title compound without further purification. LCMS m/z=273.4 [M+H]+.

Provenance & Evidence