HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1471999Generated: October 30, 2026
Potassium Carbonate → 2,5-dichloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine
https://huagongshe.com/reaction/1471999
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-(Dimethylphosphoryl)aniline | HCID 20634553 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2,5-dichloro-N-[4-(dimethylphosphoryl)phenyl]pyrimidin-4-amine | HCID 86668790 | 36.2% |
Reaction Steps
To a solution of 2,4,5-trichloropyrimidine (0.15 ml, 1.31 mmol) in 1 mL of DMF was added 4-(dimethylphosphoryl)aniline (0.221 g, 1.31 mmol) and potassium carbonate (0.217 g, 1.57 mmol). The mixture was heated at 110° C. for 4 h. It was basified with saturated sodium bicarbonate solution. The suspension was filtered and washed with ethyl acetate to give the final product (0.15 g, 36% yield). MS/ES+: m/z=316.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09012462B2 |
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| Source dataset | uspto-grants-2015_04 |
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| ORD ID | ord-c3670f113f034adbb1e27a2a3e1cda99 |
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| Source note | uspto-grants-2015_04 |
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