HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine → N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-5-methyl-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidin-4-amine | HCID 59764473 | — |
| Reactant | (5-Amino-6-methoxypyridin-2-yl)dimethylphosphine oxide | HCID 67052694 | — |
| Product | N2-[6-(dimethylphosphoryl)-2-methoxypyridin-3-yl]-5-methyl-N4-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine | HCID 68165234 | — |
Reaction Steps
This compound can be prepared as in Example 32 by reacting 2-Chloro-5-methyl-N-[2-(propan-2-ylsulfonyl)phenyl]-pyrimidin-4-amine with 6-(dimethylphosphoryl)-2-methoxypyridin-3-ylamine (prepared in Example 32).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09012462B2 |
| Source dataset | uspto-grants-2015_04 |
| ORD ID | ord-fa695d188f8649ed9ca1dab2eb83d613 |
| Source note | uspto-grants-2015_04 |