HCID 28948819, compound → HCID 68156971, compound

HRID 1472019Notes

Reaction equation

HRID 1472019 reaction equation
[Cl:1][C:2]1[C:3]([NH:26][C:27]2[CH:32]=[CH:31][C:30]([P:33]([CH3:36])([CH3:35])=[O:34])=[CH:29][C:28]=2[S:37]([CH:40]([CH3:42])[CH3:41])(=[O:39])=[O:38])=[N:4][C:5]([NH:8][C:9]2OC(N3CCN(C4C=CC=CN=4)CC3)=NN=2)=[N:6][CH:7]=1.[N:43]1([C:49]2[S:50][CH:51]=[C:52](CN)[N:53]=2)[CH2:48][CH2:47][O:46][CH2:45][CH2:44]1>>[Cl:1][C:2]1[C:3]([NH:26][C:27]2[CH:32]=[CH:31][C:30]([P:33]([CH3:35])([CH3:36])=[O:34])=[CH:29][C:28]=2[S:37]([CH:40]([CH3:41])[CH3:42])(=[O:38])=[O:39])=[N:4][C:5]([NH:8][CH2:9][C:52]2[N:53]=[C:49]([N:43]3[CH2:44][CH2:45][O:46][CH2:47][CH2:48]3)[S:50][CH:51]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 28948819HCID 28948819, compoundHCID 68157416HCID 68157416, compound

Product 1

HCID 68156971HCID 68156971, compound

Procedure

This compound can be prepared as in Example 32 by reacting 2,5-dichloro-N-[4-(dimethylphosphoryl)-2-(propan-2-ylsulfonyl)phenyl]pyrimidin-4-amine (as described in Example 53) with 1-[2-(morpholin-4-yl)-1,3-thiazol-4-yl]methanamine.

Workup

  1. customThis compound can be prepared as in Example 32

Sources & evidence

ORD record
ord-314a24f063b945e29675025ab17969de
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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